Washington University’s Clinical Genomics Laboratory processes a variety of tissue specimens for the diagnosis and monitoring of many types of cancer.

We offer chromosome analysis, FISH and FFPE FISH to detect translocations, deletions, duplications, amplifications, and to monitor the status of bone marrow transplants. We correlate the histology with FISH testing utilizing customized as well as standardized probes to assess specific genetic loci that may assist in:

  • Diagnosis of disease (e.g. IGH-CCND1, IGH-BCL2)
  • Prognosis of disease (e.g. c-MYC, n-MYC, BCR-ABL, 1p/19q)
  • Minimal residual disease (e.g. XY chimerism)
  • Targetable drug therapy (e.g. EGFR. RET, ROS1, ALK, HER2)

Chromosome Analysis
SummaryDetects aneuploidy, rearrangements, deletions, inversions
Specimen typesBone core, bone marrow aspirate, lymph node, peripheral blood, solid tumor, tissue biopsy
Turnaround times14-21 days
Fluorescence In-Situ Hybridization (FISH)
SummaryDetects aneuploidy, rearrangements, deletions and inversions associated with hematologic malignancies
Specimen typesBone core, bone marrow aspirate, lymph node, peripheral blood
Specific tests offeredAcute Myeloid Leukemia (CBFB, CEP8, D7S486, EGR1, EVI, MLL, PML/RARA, RARA, RUNX1/RUNX1T1)
B-cell Acute Lymphoblastic Leukemia (BCR/ABL, CDKN2A, CEP4/10/17, ETV6/RUNX1, IGH, MLL, TCF3)
T-cell Acute Lymphoblastic Leukemia (CDKN2A, MYC, TCR, TRB)
Chronic Lymphocytic Leukemia (ATM, BCL2, BCL6, CCND1/IGH, CEP12, D13S319, MYB, TP53)
Chronic Myleogeneous Leukemia/Myeloproliferative Disorder (BCR/ABL1, FIP1L1/PDGFRA)
Chronic Myelomonocytic Leukemia (PDGFRB)
Myelodysplastic Disorder (CEP8, D7S486, D13S319, D20S108, EGR1, ETV6)
Multiple Myeloma (CCND1/IGH, CKS1B/CDKN2C, D13S319, FGFR3/IGH, IGH/MAP, TP53)
Lymphoma (BCL6, IGH, MYC)
Anaplastic Large Cell Lymphoma (ALK)
Burkitt’s Lymphoma (CCND1/IGH, MYC)
Diffuse Large Cell Lymphoma (IGH/BCL2)
Mantle Cell Lymphoma (CCND1/IGH)
Small Cell Leukemia-Lymphoma (FGFR1)
Turnaround times24-72 hours
FFPE Fluorescence In-Situ Hybridization
SummaryDetects rearrangements, amplifications and deletions associated with solid tumors and hematologic malignancies
Specimen typesFFPE slides derived from solid tumors and tissue biospies
Specific tests offeredBreast Cancer (HER2)
Lung Cancer (ALK, EGFR, FGFR1, MET, RET, ROS1)
Neuropathologic Malignancies (BRAF, CDKN2A, EGFR, HER2, MYC, MYCN, PTEN, 1p/9q, 1p/14q, 22q)
Sarcomas (DDIT3, EWSR1, FOXO1, FUS, SS18)
Hematologic Malignancies (ALK, BCL6, BCR/ABL, BIRC3/MALT, IGH, IGH/BCL2, IGH/CCND1, MLL, MYC)
Turnaround times3-5 days